AN INSIGHT INTO THE ANTIBACTERIAL ACTIVITY OF COPPER DOPED GRAPHITIC CARBON NITRIDE COMPOSITE
DOI:
https://doi.org/10.55197/qjoest.v6i2.209Keywords:
metal doped, composite, antibiotics, bacteria, resistance, healthcare costsAbstract
The synthesis and doping of graphitic carbon nitride (g-C3N4) with copper (ii) chloride dihydride (CuCl2.2H2O) to the corresponding copper doped graphitic carbon nitride (Cu-g-C3N4) composite and also the application of the as-synthesized composite as an antibacterial agent is described. The graphitic carbon nitride (g-C3N4) was synthesized from melamine via condensation and then converted to copper doped graphitic carbon nitride (Cu-g-C3N4) by treatment with different percentage (5%, 10% and 20%) of the metal precursor to obtained Cu-g-C3N4. The resultant composite was characterized using XRD, FTIR, and FESEM. The antibacterial assay of the composite was assessed against the standard laboratory strains of Staphylococcus aureus (gram +ve), Salmonella typhi (gram –ve), Escherichia Coli (gram –ve) and Streptococcus pyogenes (gram +ve) using well diffusion method. The as-synthesized composite shows a good antibacterial activity against the test organisms (gram +ve and gram –ve) with zone of inhibition ranging between 2-21 mm. The results were found to be appreciable when compared with that of the standard antibiotic (Ampicillin). These indicate that the as-synthesized composites have good potentials for developing new antibiotics which will help in reducing healthcare costs and mortality rate due to resistance of bacteria to already manufactured drugs.
References
[1] Chu, D., Younis, A., Li, S. (2012): Enhancement of Resistance Switching in Electrodeposited Co‐ZnO Films. – International Scholarly Research Notices 4p.
[2] Cui, H., Gu, Z., Chen, X., Lin, L., Wang, Z., Dai, X., Yang, Z., Liu, L., Zhou, R., Dong, M. (2019): Stimulating antibacterial activities of graphitic carbon nitride nanosheets with plasma treatment. – Nanoscale 11(39): 18416-18425.
[3] Elavarasan, S., Baskar, B., Senthil, C., Bhanja, P., Bhaumik, A., Selvam, P., Sasidharan, M. (2016): An efficient mesoporous carbon nitride (gC 3 N 4) functionalzed Pd catalyst for carbon–carbon bond formation reactions. – RSC Advances 6(55): 49376-49386.
[4] Finch, R.G., Greenwood, D., Whitley, R.J., Norrby, S.R. (2010): Antibiotic and chemotherapy e-book. – Elsevier Health Sciences 916p.
[5] Halilu, M.E., Muhammad, I., Dangoggo, S.M., Farouq, A.A., Ahmed, A., Shamsuddeen, A.A., Suleiman, M., Yahaya, M. (2016): Phytochemical and antibacterial screening of petroleum ether and ethanol extracts of Sida cordifolia leaves. – Journal of Chemical Society of Nigeria 41(2): 137-142.
[6] Han, C., Ge, L., Chen, C., Li, Y., Xiao, X., Zhang, Y., Guo, L. (2014): Novel visible light induced Co3O4-g-C3N4 heterojunction photocatalysts for efficient degradation of methyl orange. – Applied Catalysis B: Environmental 147: 546-553.
[7] Li, C.Z., Wang, Z.B., Sui, X.L., Zhang, L.M., Gu, D.M. (2016): Graphitic-C 3 N 4 quantum dots modified carbon nanotubes as a novel support material for a low Pt loading fuel cell catalyst. – RSC Advances 6(38): 32290-32297.
[8] Liu, G., Tang, R., Wang, Z. (2014): Metal-free allylic oxidation with molecular oxygen catalyzed by gC 3 N 4 and N-hydroxyphthalimide. – Catalysis Letters 144: 717-722.
[9] Liu, M.X., Zhang, J.Y., Zhang, X.L. (2022): Application of graphite carbon nitride in the field of biomedicine: Latest progress and challenges. – Materials Chemistry and Physics 281: 10p.
[10] Montigaud, H., Tanguy, B., Demazeau, G., Alves, I., Courjault, S. (2000): C3N4: Dream or reality? Solvothermal synthesis as macroscopic samples of the C3N4 graphitic form. – Journal of Materials Science 35: 2547-2552.
[11] Muhammad, I., Pandian, S., Hopper, W. (2020): Antibacterial and antioxidant activity of p-quinone methide derivative synthesized from 2, 6-di-tert-butylphenol. – Chemistry International 6(4): 260-266.
[12] Muhammad, I., Usman, J. (2023): Antibacterial studies of molecularly engineered graphitic carbon nitride (gC 3N4) to quaternary ammonium hydroxide (gC 3N4-OH) composite: An application towards generating new antibiotics. – Chemistry International 9(3): 77-85.
[13] Pan, Y., Zheng, W., Ou, L., Yan, H., Huang, R., Pan, C. (2022): Enhancement of catalytic performance of cobalt-doped g-C3N4 catalyst by the synergistic interaction between photocatalytic and peroxymonosulfate activation system. – Journal of Materials Science: Materials in Electronics 33(23): 18897-18909.
[14] Rattan Paul, D., Nehra, S.P. (2021): Graphitic carbon nitride: a sustainable photocatalyst for organic pollutant degradation and antibacterial applications. – Environmental Science and Pollution Research 28: 3888-3896.
[15] Sanad, M.M., Taha, T.A., Helal, A., Mahmoud, M.H. (2023): Rational optimization of g-C3N4/Co3O4 nanocomposite for enhanced photodegradation of Rhodamine B dye under visible light. – Environmental Science and Pollution Research 30(21): 60225-60239.
[16] Shao, Y., Zhang, S., Engelhard, M.H., Li, G., Shao, G., Wang, Y., Liu, J., Aksay, I.A., Lin, Y. (2010): Nitrogen-doped graphene and its electrochemical applications. – Journal of Materials Chemistry 20(35): 7491-7496.
[17] Sreenivasa, S., Vinay, K., Mohan, N.R. (2012): Phytochemical analysis, antibacterial and antioxidant activity of leaf extract of Datura stramonium. – International Journal of Science Research 1(2): 83-86.
[18] Thomas, A., Fischer, A., Goettmann, F., Antonietti, M., Müller, J.O., Schlögl, R., Carlsson, J.M. (2008): Graphitic carbon nitride materials: variation of structure and morphology and their use as metal-free catalysts. – Journal of Materials Chemistry 18(41): 4893-4908.
[19] Thurston, J.H., Hunter, N.M., Wayment, L.J., Cornell, K.A. (2017): Urea-derived graphitic carbon nitride (ug-C3N4) films with highly enhanced antimicrobial and sporicidal activity. – Journal of Colloid and Interface Science 505: 910-918.
[20] Usman, H., Osuji, J.C. (2007): Phytochemical and in vitro antimicrobial assay of the leaf extract of Newbouldia laevis. – African Journal of Traditional, Complementary and Alternative Medicines 4(4): 476-480.
[21] Verma, S., Baig, R.N., Nadagouda, M.N., Varma, R.S. (2016): Selective oxidation of alcohols using photoactive VO@ g-C3N4. – ACS Sustainable Chemistry & Engineering 4(3): 1094-1098.
[22] Wang, X., Mao, W., Zhang, J., Han, Y., Quan, C., Zhang, Q., Yang, T., Yang, J., Li, X.A., Huang, W. (2015): Facile fabrication of highly efficient g-C3N4/BiFeO3 nanocomposites with enhanced visible light photocatalytic activities. – Journal of Colloid and Interface Science 448: 17-23.
[23] Wu, H., Li, C., Che, H., Hu, H., Hu, W., Liu, C., Ai, J., Dong, H. (2018): Decoration of mesoporous Co3O4 nanospheres assembled by monocrystal nanodots on g-C3N4 to construct Z-scheme system for improving photocatalytic performance. – Applied Surface Science 440: 308-319.
[24] Yang, S., Gong, Y., Zhang, J., Zhan, L., Ma, L., Fang, Z., Vajtai, R., Wang, X., Ajayan, P.M. (2013): Exfoliated graphitic carbon nitride nanosheets as efficient catalysts for hydrogen evolution under visible light. – Advanced Materials 25(17): 2452-2456.
[25] Yang, Y., Guo, Y., Liu, F., Yuan, X., Guo, Y., Zhang, S., Guo, W., Huo, M. (2013): Preparation and enhanced visible-light photocatalytic activity of silver deposited graphitic carbon nitride plasmonic photocatalyst. – Applied Catalysis B: Environmental 142: 828-837.
[26] Zhang, L., Jin, Z., Lu, H., Lin, T., Ruan, S., Zhao, X.S., Zeng, Y.J. (2018): Improving the visible-light photocatalytic activity of graphitic carbon nitride by carbon black doping. – ACS Omega 3(11): 15009-15017.
[27] Zhang, X., Xie, X., Wang, H., Zhang, J., Pan, B., Xie, Y. (2013): Enhanced photoresponsive ultrathin graphitic-phase C3N4 nanosheets for bioimaging. – Journal of the American Chemical Society 135(1): 18-21.
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Copyright (c) 2025 IBRAHIM MUHAMMAD, ABUBAKAR ISAH, JAMILU USMAN
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